MedIntelliBase® NewsTips
April/May 2008
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ResuscitationCentral.com ...
Infant Weight & Heart Disease Risk...
CREATE Registry
May 6, 2008 – New Breaking News

Visitors ResuscitationCentral.com can get free weekly clinical resuscitation abstracts through its Breaking News page...read more.
SAPPHIRE Trial
Carotid Stenting vs. CEA-3-Year SAPPHIRE Results

April 10, 2008 - SAPPHIRE Trial results at 3 years are now in. CAS (carotid artery stenting) compared to CEA (carotid endarterectomy) produced no significant difference in long-term outcomes for patients with severe carotid artery stenosis.

The New England Journal of Medicine reported, "carotid stenting using distal embolic protection vs. carotid endarterectomy in patients at high surgical risk show no significant difference between groups in the prespecified secondary end point of the trial, a composite at 3 years of death, stroke, or myocardial infarction (MI) within 30 days of the procedure or death or ipsilateral stroke between 31 and 1080 days."
VIBRANT Trial
Read more...for more information on the SAPPHIRE Trial and its results. Or click on the thumbnail image above to view its MIB MarketTracks Clinical Trial summary.
According to a study presented at the American College of Cardiology’s Scientific Session 2008 --

"Low birth weight, especially in premature babies, has been associated with poor heart health in adulthood, resulting in the traditional view that rapid weight growth after birth may be protective. However, new evidence suggests that accelerated growth in preterm and term babies is associated with a range of diseases in later life, such as heart attack, diabetes and high blood pressure..." according to Marietta Charakida, M.D., Ph.D., of University College London...read more.
ACC 2008 – 6-Month Interim Results

March 31, 2008 – First results from the CREATE Registry [Multi-Center Registry of Excel BiodegrAdable Polymer Drug EluTing StEnt] are now available.

CREATE Registry’s PI, Yaling Han MD, FSCAI Shenyang Northern Hospital, concluded that "6-month dual antiplatelet treatment seems safe after Excel stent implantation...Current data suggests a high degree of safety of the Excel biodegradable polymer coated SES, even though being used in ‘real world’ settings...Long-term (>1 yr) safety needs further investigation."
ZIPS Trial
(For an MIB MarketTracks summary of the CREATE Registry and its results click the thumbnail image above.)
CREATE, designed to assess the safety and efficacy of the ExcelTM biodegradable polymer coated sirolimus eluting stent in “real world” PCI practice, is produced by JWMS [Shandong Wuigao Group Medical - Weihai, China].

This registry examined stenting data from 2,077 patients enrolled in 59 locations in China, Indonesia, Malaysia and Thailand. The Excel biodegradable polymer sirolimus eluting stent has enjoyed strong sales in China over the last year following its approval in 2006.
Pathway Raises $24.5 Million...
April 15, 2008 - Pathway Medical Technologies Inc. [Kirkland WA] developer of medical devices used to treat arterial disease, reported it raised $24.5 million in a third round of financing which will help the company launch its first commercial product later this year...read more.
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    MIB NewTips March 2008 Issue – Volume 3, Number 2

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